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评价生物降解性的环胞素 Ａ 硬脂酸毫微球对兔眼实验性增殖性玻璃体视网膜病变的防治作用。方法： 成年健康灰兔 ３０ 只， 随机分组， 对照组 ２０ 只眼内注入 １％ 空白毫微球悬液或磷酸缓冲液 （ Ｐ Ｂ Ｓ）； 环胞素 Ａ 毫微球组 （含环胞素 Ａ０８ｍ ｇ／ｍ ｌ或 １６ｍ ｇ／ｍ ｌ， ２ 组各２０ 只眼）。各组均先后２ 次行气体压迫玻璃体手术。第二次玻璃体注气后第 ７ 天， 所有实验眼玻璃体腔内注入成纤维细胞悬液 ２×１０５ ／０１ｍ ｌ， 再分别注入空白毫微球， Ｐ Ｂ Ｓ或载药毫微球悬液 ０１ｍ ｌ。以间接检眼镜观察牵引性视网膜脱离发生情况， 共四周。结果： ４ 周末时对照组、环胞素 Ａ 毫微球 ０８ｍ ｇ／ｍ ｌ组、环胞素 Ａ 毫微球 １６ｍ ｇ／ｍ ｌ组的牵引性视网膜脱离的发生率分别为 ９０％ 、５２６％ 和３０％ ， 两个环胞素 Ａ 毫微球组与对照组相比经统计学处理有显著性差异 （ Ｐ＜ ００１）。结论： 一次性注入环胞素 Ａ 生物降解性毫微球能够有效地减少牵引性视网膜脱离的发生率。
To evaluate the preventive and therapeutic effects of biodegradable cyclosporin A stearic acid nanospheres on experimental proliferative vitreoretinopathy in rabbit eyes. Methods: Thirty healthy adult gray rabbits were randomly divided into control group (20%), blank control group (n = 10), blank control group A0 8m g / m l or 1 6m g / m l, 2 groups of 20 eyes). All groups were followed by 2 times gas compression vitreous surgery. On the 7th day after the second injection of vitreous humor, all experimental eyes were injected with 2 × 10 5 / 0.1 ml of fibroblast suspension in the vitreous cavity, and then injected into the blank nanosphere, P B S or drug-loaded nanosphere suspension Liquid 0 1m l. An indirect ophthalmoscope was used to observe the occurrence of traumatic retinal detachment for a total of four weeks. Results: The incidence of traumatic retinal detachment in the control group, cyclosporin A nanosphere 08 m g / m l group and cyclosporin A nanosphere 1 6 m g / m l group were 4 %, 52.6% and 30% respectively. There was a significant difference between the two cyclosporine A nanosphere groups and the control group (P <001). CONCLUSION: A one-time injection of cyclosporin A biodegradable nanospheres can effectively reduce the incidence of traumatic retinal detachment.