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目的:观察鱼腥草滴鼻液的局部刺激性与过敏性,为临床安全用药提供依据。方法:大鼠鼻腔滴入给药,qd,连续7d,逐日观察动物的局部刺激症状,并于给药后24h,48h和7d后分批处死动物,观察呼吸道黏膜的组织病理学变化;对豚鼠皮肤多次局部涂抹致敏,观察其过敏反应。结果:局部刺激性试验中动物一般状况良好,未发生全身反应甚至死亡情况,给药局部鼻黏膜未见红斑、水肿等刺激反应,组织病理学检查发现鼻、喉、气管、支气管等呼吸道黏膜未见损伤性变化及大量炎细胞浸润;对豚鼠皮肤的多次刺激致敏试验显示该药无致敏性。结论:鱼腥草滴鼻液局部用药无明显的刺激性和过敏性,其临床使用预期安全可靠。
Objective: To observe the local irritation and allergy of Houttuynia rhynchophylla nasal drops, and provide the basis for clinical safe medication. Methods: The rats were given nasal instillation for qd for 7 days. The local irritation of the animals was observed daily and the animals were sacrificed in batches 24h, 48h and 7d after administration. The histopathological changes of respiratory mucosa were observed. Multi-topical skin allergens, observe the allergic reaction. RESULTS: In the local irritation test, the animals were generally in good condition with no systemic reaction or even death. No irritation reaction such as erythema and edema occurred on the local nasal mucosa. Histopathological examination revealed that the mucosa of the respiratory tract such as the nose, throat, trachea and bronchus See injury changes and a large number of inflammatory cell infiltration; multiple stimulation of guinea pig skin sensitization test showed no sensitization of the drug. Conclusion: Houttuynia nasalis local anesthetic no obvious irritation and allergy, its clinical use is expected to be safe and reliable.