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目的探讨甲磺酸多沙唑嗪控释片在嗜铬细胞瘤术前准备中的效果。方法 67例功能性嗜铬细胞瘤患者分为甲磺酸多沙唑嗪控释片组(DOX组)36例和酚苄明组(PXB组)31例,两组患者通过口服药物准备,使血压、心率控制在正常范围及红细胞压积低于45%后进行手术。结果两组患者的年龄构成、术前最高血压、手术前血压、手术前红细胞压积具有可比性。DOX组的麻醉诱导前收缩压、麻醉稳定后收缩压及肿瘤切除后的最低收缩压均明显高于PXB组(P<0.01),DOX组的术中△SBP明显低于PXB组(P<0.01)。结论甲磺酸多沙唑嗪控释片具有与酚苄明相当的术前扩容能力,其降压效果略逊于酚苄明,但DOX组患者术中血压波动更小、更稳定,且术前准备时间明显短于PXB组。
Objective To investigate the effect of doxazosin mesylate controlled release tablets in the preparation of pheochromocytoma. Methods A total of 67 patients with functional pheochromocytoma were divided into doxazosin mesylate controlled release (DOX group) 36 cases and phenoxybenzamine (PXB group) 31 cases. Blood pressure and heart rate were controlled within the normal range and the hematocrit was lower than 45%. Results The age group composition, preoperative blood pressure, preoperative blood pressure, and preoperative hematocrit were comparable. The systolic blood pressure before anesthesia induction, the systolic blood pressure after anesthesia stabilization, and the minimum systolic blood pressure after tumor resection in the DOX group were significantly higher than those in the PXB group (P<0.01). The intraoperative △SBP in the DOX group was significantly lower than that in the PXB group (P<0.01). ). Conclusion The doxazosin mesylate controlled-release tablet has the ability to expand preoperatively comparable to phenoxybenzamine. Its antihypertensive effect is slightly inferior to that of phenoxybenzamine, but the blood pressure fluctuations in the DOX group are smaller and more stable. The preparation time is significantly shorter than the PXB group.