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目的探讨肝脾γδT细胞淋巴瘤的临床病理学特征、免疫表型特点。方法对1例确诊的肝脾T细胞淋巴瘤患者的临床表现、组织形态及免疫表型进行分析,并复习相关文献。结果患者男性,29岁。自发性脾破裂出血。镜下瘤细胞呈弥漫性脾窦内侵犯。免疫组化示瘤细胞CD2、CD3、CD5、granzymeB及TIA均(+)。结论肝脾T细胞淋巴瘤是较为罕见的外周T细胞淋巴瘤,目前尚无有效治疗方法,患者预后差。
Objective To investigate the clinicopathological features and immunophenotypic features of γδ T-cell lymphoma of liver and spleen. Methods The clinical manifestations, histomorphology and immunophenotypes of one patient diagnosed with hepatosplenic T-cell lymphoma were analyzed and relevant literatures were reviewed. Results The patient was male, 29 years old. Spontaneous rupture of the spleen. Microscopic tumor cells showed diffuse splenic invasion. Immunohistochemistry showed tumor cells CD2, CD3, CD5, granzymeB and TIA (+). Conclusions Hepatosplenic T-cell lymphoma is a rare peripheral T-cell lymphoma. Currently there is no effective treatment and the prognosis is poor.