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目的观察中医解郁活血法联合盐酸舍曲林片治疗卒中后抑郁症的疗效。方法将60例卒中后抑郁症患者按随机数字表法随机分为对照组和观察组各30例,对照组给予盐酸舍曲林片治疗,观察组在此基础上加用中医解郁活血法治疗,观察2组治疗效果。结果治疗后3周观察组HAMD及中医证候量化评分较治疗前明显下降(P<0.05),治疗后6周2组HAMD及中医证候量化评分均较治疗前明显下降(P均<0.05),观察组下降程度明显高于对照组(P<0.05),治疗6周后2组HAMD评分下及中医证候量化评分下治疗总有效率比较观察组均明显高于对照组(P均<0.05),2组不良反应发生率比较差异无统计学意义(P>0.05)。结论中医解郁活血法联合盐酸舍曲林片治疗卒中后抑郁症能明显提高治疗有效率,改善患者预后,可推广应用。
Objective To observe the curative effect of traditional Chinese medicine Jieyu Huoxue combined with sertraline hydrochloride on post-stroke depression. Methods Sixty patients with post-stroke depression were randomly divided into control group and observation group according to random number table method. The control group was treated with sertraline hydrochloride tablets. The observation group was treated with Chinese medicine Jieyu Huoxue Decoction , Observed two groups of treatment effect. Results After 3 weeks of treatment, the quantification of HAMD and TCM syndrome in observation group was significantly lower than that before treatment (P <0.05). After 6 weeks of treatment, the quantification of HAMD and TCM syndrome in two groups were significantly lower than those before treatment (all P <0.05) (P <0.05). After 6 weeks of treatment, the total effective rate under the HAMD score and the TCM syndrome quantification score in the observation group were significantly higher than those in the control group (all P <0.05) ), There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Chinese medicine Jieyu Huoxue combined with sertraline hydrochloride tablets in the treatment of post-stroke depression can significantly improve the treatment efficiency and improve the prognosis of patients, which can be popularized and applied.