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微RNA（ miRNA）是在真核生物中新近发现的一个内源性小分子RNA家族，具有调控靶信使RNA（ mRNA）转录、翻译、剪切靶mRNA并促进其降解的功能，被认为在机体发育过程中发挥重要作用，目前miRNA已成为肿瘤研究领域的热点。 miRNA 参与皮肤肿瘤的疾病进展，对 miRNA的深入研究能增进对皮肤肿瘤发生、发展、转归等机制的认识，促进皮肤肿瘤诊断和治疗的快速发展。“,”MicroRNA( miRNA) is a newly discovered endogenous small messenger RNA ( mRNA) fam-ily in eukaryotes,with the function of regulating mRNA transcription,translation,cutting target mRNA and pro-moting its degradation.It is thought to play an important role in the process of body development.Especially,it plays a significant role in the pathogenesis of tumor,studies have shown that miRNA is involved in the patho-genesis of melanoma progression.The intensive study of the miRNA undoubtedly can strengthen understand-ing of the occurrence,development and prognosis of skin cancer,and promote the rapid development of the diagnosis and treatment.