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目的:评价重组人黄体生成素(r-hLH)在高龄患者促排卵中的应用价值以及对临床结局的影响。方法:选择协和医院生殖中心进行试管婴儿治疗,长方案降调节,年龄≥35岁,卵泡刺激素促排卵第7天,血清LH水平低于2U/L的患者146例。根据是否使用r-hLH进行分组:A组78例给予r-hLH治疗,B组68例未给予r-hLH治疗。比较两组患者的血清LH水平变化、平均促性腺激素(Gn)使用量、获卵数、双原核胚胎数、优质胚胎率、着床率及临床妊娠率。结果:两组患者血清LH变化情况、平均Gn用量、获卵数、优质胚胎率差异无统计学意义(P>0.05);A组的平均双原核胚胎数、着床率及临床妊娠率均显著高于B组(P<0.05)。结论:对于卵泡刺激素促排卵第7天血清LH<2U/L的高龄患者,补充r-hLH可以获得较高的双原核胚胎数、着床率及临床妊娠率。
OBJECTIVE: To evaluate the value of recombinant human luteinizing hormone (r-hLH) in ovulation induction in elderly patients and its impact on clinical outcomes. Methods: 146 cases of IVF treated with IVF, long-term regimen reduction, age ≥35 years, follicle-stimulating hormone induced ovulation 7 days and serum LH level less than 2U / L were selected. According to whether to use r-hLH grouping: 78 patients in group A received r-hLH treatment, 68 patients in group B were not given r-hLH treatment. The changes of serum LH level, average amount of gonadotropin (Gn) usage, number of oocytes retrieved, number of pronuclear embryos, quality embryo rate, implantation rate and clinical pregnancy rate were compared between the two groups. Results: There was no significant difference in serum LH, average amount of Gn, number of oocytes retrieved and quality embryos between the two groups (P> 0.05). The average number of embryos, implantation rate and clinical pregnancy rate in group A were significantly Higher than the B group (P <0.05). CONCLUSION: The r-hLH r-hH can obtain higher numbers of embryos, implantation rate and clinical pregnancy rate in LH patients with serum LH <2U / L on the 7th day after ovulation induction of follicle stimulating hormone.