[Objective] The antioxidation effect of Carya cathayensis sarg (CCS) Oil was qualitatively and quantitatively detected.[Method] 50 male mice were divided into 5 groups equally and randomly and among them,the three groups were either negative, or model control, or positive control (ginseng saponins), respectively.Two remaining groups were orally fed with low and high dosages of CCS oil ((9 ml/(kg·d) and (33 ml/(kg·d)), respectively.All groups were injected D galactose through hypodermic except the negative control ones which were only treated with equals amount of distilled water.The superoxide dismutase (SOD), maleic dialdehyde(MDA) and monoamine oxidase(MAO) were analyzed with blood sample and brain tissue 42 days post treatment.[Result] It was showed that the activity of SOD enzyme was increased in the CCS oil groups, while MDA and MAO content were decreased in the CCS oil groups compared with that of other groups with significance observed in the group fed with high dose of CCS oil.[Conclusion] The result indicated that the CCS oil has the ability of antioxidation and is useful to human health.