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目的研究急性脑梗死老年患者洋葱伯克霍尔德菌感染的临床特点和耐药性,为合理选用抗菌药物治疗洋葱伯克霍尔德菌感染提供依据。方法选取2010年1月-2013年12月洋葱伯克霍尔德菌感染的74例老年患者为研究对象,对所有患者感染洋葱伯克霍尔德菌的分布和耐药性进行回顾性分析,采用SPSS 15.0软件进行统计分析。结果 74例急性脑梗死洋葱伯克霍尔德菌感染老年患者送检标本主要分布在痰液中,共57株占77.0%;洋葱伯克霍尔德菌对头孢他啶的耐药率为47.3%,对磺胺甲噁唑/甲氧苄啶的耐药率为8.1%;对头孢他啶耐药性明显高于米诺环素、美罗培南和磺胺甲噁唑/甲氧苄啶。结论急性脑梗死长期住院的老年患者洋葱伯克霍尔德菌感染临床上主要分布在痰液中,少量见于血液中;对米诺环素、美罗培南基本无耐药性,而对头孢他啶有较高的耐药性。
Objective To study the clinical features and drug resistance of Burkholderia cepacia in elderly patients with acute cerebral infarction and provide evidence for rational use of antibacterials for the treatment of Burkholderia cepacia. Methods A total of 74 elderly patients with Burkholderia cepacia infection from January 2010 to December 2013 were selected as the research object to investigate the distribution and drug resistance of Burkholderia cepacia in all patients. SPSS 15.0 software for statistical analysis. Results Seventy-four cases of Burkholderia cepacia infection in elderly patients with acute cerebral infarction were mainly located in sputum with 57 strains accounting for 77.0%. Burkholderia cepacia resistant to ceftazidime was 47.3% The resistance rate to sulfamethoxazole / trimethoprim was 8.1%. The resistance to ceftazidime was significantly higher than that of minocycline, meropenem and sulfamethoxazole / trimethoprim. CONCLUSIONS: Burkholderia cepacia is mainly found in sputum in a small number of elderly patients with long-term hospital stay in acute cerebral infarction. There is little resistance to minocycline and meropenem, but ceftazidime is more effective than ceftazidime High resistance.