左旋心得乐(Levobunolol)系一种非选择性β-肾上腺素能阻滞剂,具有长期降低眼内压作用。为了确定局部使用Levobunolol控制眼内压所需的最低浓度,作者对50例轻度开角型青光眼或高眼压症者作了以噻吗心安为对照的双盲、随机滴定度研究。病人眼内压均≥23mmHg。开始以最低浓度的药物进行治疗,然后滴定到疗效所需的最低浓度。药物浓度选用:噻吗心安为0.125％、0.25％及0.5％;Levobunolol为0.25％、0.5％及1％。 Levobunolol, a non-selective beta-adrenergic blocker, has long-term effects of lowering intraocular pressure. To determine the minimum concentration required for topical use of Levobunolol to control intraocular pressure, we conducted a double-blind, randomized titer study of timolol in 50 patients with mild open-angle glaucoma or ocular hypertension. Intraocular pressure in patients with ≥ 23mmHg. Begin treatment with the lowest concentration of drug and then titrate to the lowest concentration required for efficacy. Drug concentration selection: timolol 0.125%, 0.25% and 0.5%; Levobunolol 0.25%, 0.5% and 1%.