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目的探讨喉鳞状细胞癌(LSCC)组织中表皮生长因子受体(EGFR)、p27和皮层肌动蛋白(cortactin)表达与术后肿瘤局部复发的关系。方法采用免疫组化法检测60例喉癌组织原发灶EGFR、p27和皮层肌动蛋白表达情况并进行免疫染色评分。对患者临床病理因素及EGFR、p27和皮层肌动蛋白表达与喉癌术后局部复发情况进行多因素Logistic回归分析。结果多因素分析显示,EGFR、p27和皮层肌动蛋白表达是喉癌术后局部复发的独立影响因素(P=0.020,0.010,0.008),EGFR和皮层肌动蛋白高表达是局部复发的危险因素(β=1.244,1.639),p27高表达是局部复发的保护因素(β=-1.390)。喉癌术后局部复发与年龄、性别、临床分期和病理分化无关。结论EGFR、p27和皮层肌动蛋白表达与喉癌术后局部复发相关。EGFR、p27和皮层肌动蛋白三个因子可能成为预测喉鳞状细胞癌术后复发的生物标记物。
Objective To investigate the relationship between the expression of epidermal growth factor receptor (EGFR), p27 and cortactin in laryngeal squamous cell carcinoma (LSCC) and local recurrence of tumor. Methods The expressions of EGFR, p27 and cortical actin in 60 primary laryngeal cancer tissues were detected by immunohistochemistry and immunostained. The multivariate logistic regression analysis was performed on the clinicopathological factors and the expression of EGFR, p27 and cortical actin in the patients with local recurrence of laryngeal cancer. Results Multivariate analysis showed that the expression of EGFR, p27 and cortical actin were independent risk factors for local recurrence of laryngeal carcinoma (P = 0.020,0.010,0.008). The high expression of EGFR and cortical actin were risk factors for local recurrence (β = 1.244,1.639), p27 overexpression is a protective factor of local recurrence (β = -1.390). Local recurrence of laryngeal cancer has no relation with age, sex, clinical stage and pathological differentiation. Conclusion The expressions of EGFR, p27 and cortical actin are related to the local recurrence of laryngeal cancer. EGFR, p27 and cortical actin may be the biomarkers for predicting the recurrence of laryngeal squamous cell carcinoma.