在前报中我们介绍了以水溶性高分子材料为基质的蚀解片的体内体外释药研究。本文报道用一种高分子材料的微孔膜制备的恒释片剂,控制其按零级动力学释药的实验。用微孔膜来控制药物释放,是国外近年来发展起来的一种新技术。其原理是,将药片用微孔膜包衣,当该包衣片置水中后,水透过微孔膜溶解其中的药物到一定程度,该药物的水溶液便产生一定的渗透压,阻止水分继续 In the previous report, we introduced the in vitro and in vitro release studies of water-soluble polymer-based erodible tablets. This paper reports a constant release tablet prepared with a microporous membrane of a polymeric material to control its release in a zero-order kinetic. Microporous membrane to control drug release, is a new technology developed in recent years abroad. The principle is that the tablets are coated with a microporous membrane. When the coated tablet is put in water, the water permeates through the microporous membrane to dissolve the drug therein to a certain extent, and the aqueous solution of the drug will generate a certain osmotic pressure to prevent the water from continuing