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In this study,the process of a biodegradable polylactide(PLA) microsphere encapsulating ginsenoside Rg3 was first studied by the emulsion solvent evaporation method,for enhancing solubility and stability of ginsenoside Rg3.Alabum was also first used as a modifier in this method.The mean diameter of the prepared PLA microspheres containing Rg3 was 40 μm.Ginsenoside Rg3 released from the microspheres was studied by HPLC and detected by UV.It was found that the drug release curve fitted the Model Heller-Baker best.