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应用高脂饮食培养颈动脉粥样硬化模型兔(高脂组),用ELA SA法检测模型兔不同阶段血清氧化低密度脂蛋白(ox-LDL)、可溶性细胞间黏附分子-1(sICAM-1)含量,并与对照组及服用辛伐他汀组进行比较。结果显示,4周末,高脂组ox-LDL含量较对照组明显升高(P<0.05),sICAM-1无明显变化;8周末、12周末高脂组ox-LDL及sICAM-1含量逐渐升高,12周末较8周末显著升高(P<0.01);辛伐他汀组二者各阶段升高,但无统计学意义。表明ox-LDL、sICAM-1共同参与了动脉粥样硬化的发生、发展过程,并与动脉粥样硬化程度呈正相关,可作为病情监测的血清学指标。
The rabbits in the atherosclerosis model (hyperlipidemia group) were cultured with high-fat diet. The levels of serum ox-LDL, sICAM-1 ) Content, compared with the control group and taking simvastatin group. The results showed that at the end of the 4th week, the content of ox-LDL in high-fat group was significantly higher than that in the control group (P <0.05), while sICAM-1 had no significant change. (P <0.01). The levels of simvastatin group increased at each stage, but there was no statistical significance. These results suggest that ox-LDL and sICAM-1 are involved in the development and progression of atherosclerosis. They are positively correlated with the degree of atherosclerosis and may be used as serological indicators for disease surveillance.