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目的探讨直肠恶性间质瘤的诊断及外科手术联合分子靶向药物治疗的效果。方法对我院2003年3月～2007年3月间收治的直肠恶性间质瘤7例的临床资料进行回顾性分析。结果本组无围手术期死亡病例。本组术后均接受伊马替尼辅助治疗。术后11个月局部复发再次行手术治疗1例,术后23个月发生肝转移再次手术治疗1例。所有病人均存活至今。结论手术切除联合分子靶向药物是直肠恶性间质瘤最有效的治疗手段。
Objective To investigate the diagnosis of rectal malignant stromal tumors and the effect of surgical treatment combined with molecular targeted drugs. Methods The clinical data of 7 patients with rectal malignant stromal tumors admitted to our hospital from March 2003 to March 2007 were analyzed retrospectively. Results There were no perioperative deaths in this group. This group were receiving imatinib adjuvant therapy. One case was treated with local recurrence 11 months after operation and another case was treated with liver metastasis 23 months after operation. All patients survived to this day. Conclusion Surgical resection combined with molecular targeted drugs is the most effective treatment of rectal malignant stromal tumors.