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目的探讨老年男性睾水平与冠心病发病危险因素的相关性。方法用化学发光法测定84例经冠状动脉造影证实为冠心病(CHD)组的患者及31例经冠状动脉造影证实无冠状动脉病变的对照组血清睾酮水平,同时测定血清总胆固醇(TC)、甘油三酯(TG)高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、超敏C反应蛋白(hs-CRP),并调查年龄、体质指数(BMI)、血压、是否吸烟。根据冠状动脉造影检查结果判断狭窄程度并累积积分。结果冠心病组睾酮水平与对照组比较差异有统计学意义[(3.12±1.45)vs(4.58±1.12)μg/L,t=5.071,P=0.000)];CHD组高血压,糖尿病的比例高于对照组(P均﹤0.05)。多元Logistic回归分析显示,血清睾酮为CHD独立危险因素;血清睾酮与CHD冠状动脉狭窄程度呈负相关。结论血清睾酮水平降低可能也是老年男性冠心病发病的危险因素之一,在预防老年男性冠心病危险因素的同时也应关注血清睾酮降低的防治。
Objective To investigate the correlation between testicular levels and the risk factors of coronary heart disease in elderly men. Methods The levels of serum testosterone in 84 patients with coronary heart disease (CHD) confirmed by coronary angiography and 31 patients with coronary artery disease confirmed by coronary angiography were determined by chemiluminescence. Serum total cholesterol (TC) TG, HDL-C, LDL-C and hs-CRP were measured and age, body mass index (BMI), blood pressure, Smoking. According to the results of coronary angiography to determine the degree of stenosis and accumulate points. Results The serum levels of testosterone in CHD group were significantly different from those in control group [(3.12 ± 1.45 vs 4.58 ± 1.12 μg / L, t = 5.071, P = 0.000) In the control group (all P <0.05). Multiple logistic regression analysis showed that serum testosterone was an independent risk factor for CHD. Serum testosterone was negatively correlated with the degree of coronary artery stenosis in patients with CHD. Conclusions The decrease of serum testosterone level may be one of the risk factors of coronary heart disease in elderly men. Prevention of coronary heart disease risk factors in elderly men should also be concerned with the prevention and treatment of serum testosterone lowering.