目的分析甲泼尼龙联合丙种球蛋白对病毒性脑炎重症患儿康复进程及不良反应发生率的影响。方法重症病毒性脑炎患儿80例,随机分为观察组和对照组,各40例。对照组给予甲泼尼龙治疗,观察组给予甲泼尼龙+丙种球蛋白治疗。比较两组临床疗效、不良反应发生率、症状消失时间及住院时间,两组Ig G、Ig M水平变化。结果治疗后观察组疗效高于对照组(χ~2=5.165,P=0.023);两组发热、抽搐、昏迷、肢体瘫痪等症状消失时间及住院时间均短于对照组(t_1=6.419,P_1=0.000,t_2=9.973,P_2=0.000);Ig G、Ig M水平高于对照组(t_1=8.481,P_1=0.000,t_2=3.534,P_2=0.000);不良反应发生率与对照组比较差异无统计学意义(χ~2=0.157,P=0.692)。结论甲泼尼龙联合丙种球蛋白治疗重症病毒性脑炎患儿效果显著,能有效缩短症状改善时间,促进患儿康复,安全性较高。 Objective To analyze the influence of methylprednisolone combined with gamma globulin on the rehabilitation process and the incidence of adverse reactions in children with severe viral encephalitis. Methods Eighty children with severe viral encephalitis were randomly divided into observation group and control group, 40 cases each. The control group was treated with methylprednisolone, and the observation group was given methylprednisolone + gamma globulin. The clinical efficacy, the incidence of adverse reactions, the disappearance of symptoms and the length of hospital stay were compared between the two groups. Changes of Ig G and Ig M levels were compared between the two groups. Results The curative effect of the observation group after treatment was higher than that of the control group (χ ~ 2 = 5.165, P = 0.023). The disappearance time and hospitalization time of fever, convulsion, coma and limb paralysis in both groups were shorter than those in the control group = 0.000, t 2 = 9.973, P 2 = 0.000). The levels of Ig G and Ig M were higher than those of the control group (t 1 = 8.481, P 1 = 0.000, t 2 = 3.534, P 2 = 0.000) Statistical significance (χ ~ 2 = 0.157, P = 0.692). Conclusion The combination of methylprednisolone and gamma globulin in children with severe viral encephalitis has a significant effect, which can effectively shorten the time for symptom improvement and promote the rehabilitation of children with high safety.