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脑啡肽是1975年从猪脑中提取到的具有吗啡样作用的两个五肽,即甲硫氨酸五肽及亮氨酸五肽(简称甲硫肽及亮肽)的混合物。用免疫荧光技术证明脑啡肽在脑内有自己的神经原系统,说明它根可能是一种新的递质。中国科学院上海生物化学研究所于1976年4月合成了脑啡肽,以下是我们当时进行的初步药理检定的结果。
The enkephalin is a morphine-like pentapeptide extracted from porcine brain in 1975, which is a mixture of methionine pentapeptide and leucine pentapeptide (methyl thiol and light peptide). Immunofluorescence showed that enkephalin had its own neuronal system in the brain, suggesting that it may be a new neurotransmitter. The enkephalin was synthesized in April 1976 by the Shanghai Institute of Biochemistry, Chinese Academy of Sciences. The following is the result of the preliminary pharmacological test we conducted at the time.