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目的:探讨中药组方自拟五黄汤治疗Ⅲ型前列腺炎(慢性非细菌性前列腺炎,CNBP)的机制,将中医药治疗的作用机制推进到分子水平。方法:将90例CNBP患者分为2组,每组45例,分别采用西药、中西药结合进行治疗,并对治疗前、后前列腺液常规、白介素-1β(IL-1β)、肿瘤坏死因子(TNF-α)等指标进行统计分析。结果:患者经自拟五黄汤配合西药治疗后的IL-1β、TNF-α水平与西药单独治疗后比较显著下降,临床症状明显改善。结论:自拟五黄汤能明显改善CNBP患者症状,显著降低患者前列腺液中IL-1β、TNF-α水平,是较为有效的治疗CNBP临床经验方。
Objective: To explore the mechanism of traditional Chinese medicine prescription self Wuhuang decoction for the treatment of type Ⅲ prostatitis (chronic non-bacterial prostatitis, CNBP) mechanism, to promote the mechanism of action of traditional Chinese medicine to the molecular level. Methods: Ninety patients with CNBP were divided into two groups (n = 45 each). The patients were treated with western medicine and western medicine respectively. The levels of IL-1β, TNF, TNF-α) and other indicators for statistical analysis. Results: The levels of IL-1β and TNF-α in patients treated with self-made Wuhuang decoction combined with western medicine significantly decreased after treatment with Western medicine alone, and the clinical symptoms were significantly improved. CONCLUSION: Self-prepared Wuhuang Decoction can significantly improve the symptoms of CNBP patients and significantly reduce the levels of IL-1β and TNF-α in prostatic fluid of patients. It is a more effective clinical experience in the treatment of CNBP.