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盐酸氯丙嗪在醋酸介质中以过氯酸滴定时被氧化成红色,致使滴定终点时结晶紫的变色不易辨认。本文报导,加入抗坏血酸可阻止红色氧化产物的生成,因而不干扰滴定。精密秤取盐酸氯丙嗪0.15～0.3克,溶于50毫升冰醋酸中,加八10毫升5%醋酸汞的醋酸液、1.0克抗坏血酸、2滴结晶紫指示液,搅拌,以0.1N 过氯酸滴定至由紫变蓝色。片剂可不必预先分离赋形剂,秤取20片研细,准确秤取相当盐酸氯丙嗪0.15～0.3
Chlorpromazine hydrochloride in acetic acid medium perchloric acid titration was oxidized to red, resulting in titration end of crystal violet color is not easy to identify. This article reports that the addition of ascorbic acid prevents the formation of red oxidation products and therefore does not interfere with titration. Precision scale to take chlorpromazine hydrochloride 0.15 ~ 0.3 grams, dissolved in 50 ml of glacial acetic acid, add eight 10 ml of 5% acetic acid in acetic acid, 1.0 g of ascorbic acid, 2 drops of crystal violet indicator solution, stirring to 0.1N chlorine Acid titration from purple to blue. Tablets do not have to be pre-separated excipients, weighing 20 research fine, accurately weighed amount of chlorpromazine hydrochloride 0.15 ~ 0.3