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目的探讨全囊胚冷冻复苏移植的临床应用价值。方法回顾性比较分析在淮安市妇幼保健院生殖中心行全囊胚玻璃化冷冻复融的患者共52个周期和行分裂期胚胎冷冻复苏的患者51个周期的临床结局;结果玻璃化冷冻复苏囊胚移植的患者,胚胎种植率、临床妊娠率显著高于冷冻复苏分裂期胚胎的患者(40.17%vs27.27%,P<0.05;76.92%vs41.17%,P<0.05),而多胎率显著降低(2.50%vs28.57%)(P<0.05)。结论对第三天优质胚胎数≥6枚,有卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)高危倾向、新鲜周期不宜移植的患者,行囊胚培养后进行全囊胚的玻璃化冷冻,择期复苏移植可以提高胚胎种植率和临床妊娠率,同时降低多胎妊娠率。
Objective To investigate the clinical value of whole-cell embryo cryopreservation and transplantation. Methods A total of 52 cycles of cryogenic and thawed whole-cell vitrification and 51 cycles of frozen-thawed and resuscitated embryonic cycles in the Reproductive Center of Huaian MCH Hospital were retrospectively analyzed. Results The vitrification Embryo implantation rate, embryo implantation rate and clinical pregnancy rate were significantly higher than those of cryopreservation and split-phase embryos (40.17% vs27.27%, P <0.05; 76.92% vs41.17%, P <0.05) Decreased (2.50% vs28.57%) (P <0.05). Conclusions On the third day, the number of high quality embryos is more than 6, and the patients with high risk of ovarian hyperstimulation syndrome (OHSS) who are not suitable for transplanting fresh cycles, undergo vitrification of whole blastocysts after blastocyst culture and elective resuscitation Transplantation can improve embryo implantation rates and clinical pregnancy rates, while reducing multiple pregnancy rates.