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14(男7、女7)例慢性Chagas病(南美锥虫病)心肌炎患者,年龄30~59岁.其常规心电图具有两条或两条以上的下列特征:室性早搏(VPB)多形性,R on T现象,成对VPB,短阵室性心动过速(VPB≥3次,短阵VT).主要症状有:心悸(12例),非典型性胸痛(9例),眩晕发作(4例)及中度呼吸困难(4例).12例传导阻滞:其中右束支阻滞(RBBB)8例(5例伴左前分支阻滞,1例伴左后分支阻滞),不完全性RBBB4例(其中3例伴左前分支阻滞).各例均无持续性室性心律失常或心脏骤停,也无电解质紊乱,未使用心脏活性药物.试验前记录24小时动态心电图(Holter).口服药物试验顺序如下:第1周安慰剂;第2周维拉帕米(80mg,四次/日);第3周安慰剂;第4周17-Mono-
14 (male 7, female 7) patients with chronic Chagas disease (Chagas disease) myocarditis, aged 30 to 59 years whose conventional electrocardiogram has two or more of the following characteristics: VPB pleomorphism , R on T phenomenon, paired VPB, paroxysmal ventricular tachycardia (VPB≥3 times, short-term VT) .The main symptoms were palpitations (12 cases), atypical chest pain (9 cases), vertigo 4 cases) and moderate dyspnea (4 cases) .12 cases of conduction block: including 8 cases of right bundle branch block (RBBB) (5 cases with left anterior branch block and 1 case with left posterior branch block), not Complete RBBB 4 cases (including 3 cases with left anterior branch block) .There was no persistent ventricular arrhythmia or cardiac arrest in each case, no electrolyte disturbance, no cardiac active drugs.After the test recorded 24-hour Holter ) The oral drug test sequence was as follows: Week 1 Placebo; Week 2 Verapamil (80 mg, qd / day); Week 3 Placebo; Week 4 17-Mono-