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目的研究糖尿病性胃轻瘫患者胃动力学异常的机制．方法非胰岛素依赖性糖尿病（ｎｏｎｉｎｓｕｌｉｎｄｅｐｅｎｄｅｎｔｄｉａｂｅｔｅｓｍｅｌｉｔｕｓ，ＮＩＤＤＭ）患者３２例，正常人２２例作对照．采用同位素方法测定固体液体胃排空．另外，用胃频谱图机做胃频谱分析．结果ＮＩＤＤＭ患者的固体液体胃半排空时间较正常对照组明显延缓／ｍｉｎ．（９１５±２３７ｖｓ４９２±９２及５９１±１１４ｖｓ３３２±１４８，Ｐ＜００１），固体胃排空延迟主要在排空３０ｍｉｎ以后，液体胃排空延迟主要在６０ｍｉｎ以后；ＮＩＤＤＭ患者中糖尿病性胃轻瘫检出率为５６３％；ＮＩＤＤＭ胃轻瘫患者伴有胃动过速者（４４４％）多于ＮＩＤＤＭ不伴胃轻瘫的患者（７１％，Ｐ＜００５）；ＮＩＤＤＭ患者的胃排空延迟与自主神经病变有关（Ｐ＜００１）；ＮＩＤＤＭ患者的胃排空延迟与外周神经病变、肾脏病变、空腹血糖和病程无关（Ｐ＞００５）．结论ＮＩＤＤＭ患者胃固体液体胃排空延迟，胃轻瘫检出率５６３％，其特点：固体液体胃排空延迟和胃节律紊乱．自主神经病变是引起糖尿病性胃轻瘫的重要因素．
Objective To study the mechanism of gastric motility abnormalities in diabetic gastroparesis. Methods 32 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 22 normal subjects served as controls. Isotopic determination of solid liquid gastric emptying. In addition, stomach spectrum machine with stomach spectrum analysis. Results NIDDM patients with solid liquid gastric emptying time was significantly delayed / min. (915 ± 237vs492 ± 92 and 591 ± 114vs332 ± 148, P <001). The delayed gastric emptying was mainly caused by the emptying of the liquid stomach The emptying delay was mainly after 60min; the detection rate of diabetic gastroparesis was 56.3% in NIDDM patients; the patients with NIDDM gastroparesis were more likely to have tachycardia (444%) than NIDDM patients Gastric palsy patients (7.1%, P <005); NIDDM patients with gastric emptying delay and autonomic neuropathy (P <001); NIDDM patients with gastric emptying delay and peripheral neuropathy, Nephropathy, fasting blood glucose and duration of disease has nothing to do (P> 0 05). Conclusion Gastric fluid in patients with NIDDM has delayed gastric emptying and the rate of gastroparesis is 563%. It is characterized by delayed gastric emptying and gastric disturbances in solid fluid. Autonomic neuropathy is an important factor in causing diabetic gastroparesis.