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目的探讨急性缺血性脑卒中患者血清胱抑素C水平与脑白质病变(WMLs)的相关性。方法符合诊断标准的缺血性脑卒中患者105例,根据Fazekas量表评估WMLs严重程度分为无或轻度WMLs组和重度WMLs组,比较两组相关资料的差异,分析重度WMLs的危险因素。结果两组年龄、高血压和胱抑素C水平存在统计学差异(P<0.05)。年龄(OR=1.06,95%CI=1.01~1.12,P<0.05)和胱抑素C水平(OR=1.32,95%CI=1.07~1.55,P<0.01)是急性缺血性脑卒中患者伴发重度WMLs的独立危险因素。结论年龄和胱抑素C水平是急性缺血性脑卒中患者伴发重度WMLs的独立危险因素。
Objective To investigate the correlation between serum cystatin C level and white matter lesions (WMLs) in patients with acute ischemic stroke. Methods 105 patients with diagnostic criteria of ischemic stroke were divided into mild or mild WMLs group and severe WMLs group according to the severity of WMLs according to the Fazekas scale. The differences of the related data were compared and the risk factors of severe WMLs were analyzed. Results There was a significant difference between the two groups in age, hypertension and cystatin C (P <0.05). Age (OR = 1.06, 95% CI = 1.01-1.12, P <0.05) and cystatin C level (OR = 1.32, 95% CI = 1.07-1.55, P <0.01) were associated with acute ischemic stroke Independent risk factors for severe WMLs. Conclusions Age and cystatin C levels are independent risk factors for severe WMLs in patients with acute ischemic stroke.