近几年来耐青霉素的细菌尤共是萄葡球菌有所增加,其主要原因是由于青霉素的广泛应用,致使敏感菌株逐渐消失耐药菌株逐渐增加,青霉素的疗效因而下降。耐药葡萄球菌之所以耐药是由于它们产生一种青霉素酶,这酶可破坏青霉素,使其在体内失去杀菌作用(见图1)。1959年 Batchelor 发现如改变青霉素产生菌之发酵条件,则可从发酵液中提取到纯青霉 In recent years, the penicillin-resistant bacteria in particular, Staphylococcus aureus has increased, the main reason is due to the widespread use of penicillin, resulting in the gradual disappearance of sensitive strains of resistant strains, penicillin efficacy decreased. Drug-resistant Staphylococcus aureus is resistant because they produce a penicillinase, the enzyme can destroy penicillin, so that it will lose its bactericidal effect in the body (see Figure 1). Batchelor found in 1959, such as changing the penicillin-producing bacteria fermentation conditions, you can extract from the fermentation broth to pure Penicillium