本文评价了使用顺铂、解毒药硫代硫酸钠(STS)和血管紧张素Ⅱ(AT-Ⅱ)治疗大鼠腹腔播散性癌的疗效。雌性WKA 大鼠于腹腔接种10~6活的RBT-Ⅰ细胞后的第4或第7天接受治疗。iv AT-Ⅱ(16.5μg/kg,浓度为1μg/ml),共持续11min;当开始iv AT-Ⅱ1min 后,快速ip 15mg/kg 顺铂(3ml/200g体重);iv AT-Ⅱ结束后立即iv 1580mg/kgSTS(与顺铂的克分子比为1:200),iv 持续5min,该方法称之为改良的联合给药方案 This article evaluated the efficacy of cisplatin, detoxification agents sodium thiosulfate (STS) and angiotensin II (AT-II) in the treatment of peritoneal disseminated carcinoma in rats. Female WKA rats were treated on the 4th or 7th day after intraperitoneal inoculation with 10 to 6 viable RBT-I cells. iv iv AT-II (16.5μg / kg at a concentration of 1μg / ml) for 11min; iv ip 15mg / kg cisplatin (3ml / 200g body weight) iv 1580 mg / kg STS (molar ratio of cisplatin 1: 200), iv for 5 min, this method is referred to as a modified combination regimen