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目的观察轻、中度缺氧对脑事件相关电位（ＥＲＰ）的影响，比较不同刺激模式诱发的ＥＲＰ对缺氧的敏感性。方法１２名受试者在地面、２５００ｍ和４３００ｍ模拟高度（吸入低氧混合气）分别进行视觉Ｏｄｄｂａｌ、Ｓｔｅｒｎｂｅｒｇ记忆量（ＭＳＥＴ）为１和ＭＳＥＴ为３的任务测试，记录ＥＲＰ的Ｐ３潜伏期、波幅和反应时（ＲＴ）及反应错误率（ＥＲ）。结果４３００ｍ高度缺氧时Ｐ３潜伏期显著延长，任务难度较大时（Ｓｔｅｒｎｂｅｒｇ模式ＭＳＥＴ＝３）ＥＲ增高；２５００ｍ高度缺氧时各指标无明显改变；以Ｓｔｅｒｎｂｅｒｇ模式ＭＳＥＴ＝１诱发的ＥＲＰ波形清晰，缺氧时Ｐ３潜伏期延长显著。结论４３００ｍ高度缺氧对ＥＲＰ有明显影响，Ｐ３潜伏期是评定缺氧时脑认知能力降低的敏感指标。Ｓｔｅｒｎｂｅｒｇ模式ＭＳＥＴ＝１诱发的ＥＲＰ对缺氧敏感，是一种较为理想的刺激模式。
Objective To observe the effect of light and moderate hypoxia on brain-related potential (ERP) and to compare the sensitivity of ERP to hypoxia induced by different stimulation modes. Methods Twelve subjects were tested on visual Oddbal, Sternberg memory 1 (MSET) 1 and MSET 3 at 2500m and 4300m mimics, respectively. The latency, amplitude and Reaction time (RT) and reaction error rate (ER). Results P3 latency was significantly prolonged at 4300 m altitude hypoxia. The ER increased when the task was more challenging (MSET = 3 in Sternberg mode), but no significant changes at 2500 m altitude. The ERP waveform induced by Sternberg MSET = 1 was clear and lacking P3 hyperextension prolonged significantly. Conclusion High hypoxia at 4300 m has a significant effect on ERP, and P3 latency is a sensitive index for assessing cognitive decline in hypoxia. Sternberg mode MSET = 1-induced ERP is sensitive to hypoxia and is an ideal stimulating mode.