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目的探讨胃癌组织中Ezrin蛋白的表达及其与胃癌临床病理特征的关系。方法采用S-P免疫组化法检测50例胃癌组织、30例胃黏膜不典型增生和30例正常胃黏膜中Ezrin蛋白的表达。结果Ezrin蛋白在正常胃黏膜、不典型增生和胃癌组织中的阳性表达率分别为30.0%、36.7%和86.0%,Ezrin的表达在正常胃黏膜和胃癌以及不典型增生和胃癌之间有显著差异(P<0.05)。Ezrin蛋白的表达程度与胃癌的临床分期、淋巴结转移及浸润深度有关(P<0.05),与胃癌分化程度、性别无关(P>0.05)。结论Ezrin蛋白在胃癌中的高表达与胃癌的临床分期、淋巴结有无转移及浸润深度有关,对其的检测可能成为预测胃癌转移及预后的重要指标。
Objective To investigate the expression of Ezrin protein in gastric cancer tissues and its relationship with clinicopathological features of gastric cancer. Methods The expression of Ezrin protein in 50 cases of gastric carcinoma, 30 cases of gastric dysplasia and 30 cases of normal gastric mucosa was detected by S-P immunohistochemistry. Results The positive rates of Ezrin protein in normal gastric mucosa, atypical hyperplasia, and gastric cancer tissues were 30.0%, 36.7%, and 86.0%, respectively. Ezrin expression was significantly different between normal gastric mucosa and gastric cancer, as well as dysplasia and gastric cancer. (P<0.05). The expression of Ezrin protein was related to the clinical stage, lymph node metastasis and infiltration depth of gastric cancer (P<0.05), but not to the differentiation degree and gender of gastric cancer (P>0.05). Conclusion The high expression of Ezrin protein in gastric cancer is related to the clinical stage of gastric cancer, lymph node metastasis, and the depth of invasion. The detection of Ezrin protein may be an important indicator to predict the metastasis and prognosis of gastric cancer.