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目的:观察米索前列醇预防剖宫产术中术后出血的效果。方法:选择120例择期剖宫产者,随机分为米索前列醇组及催产素组。米索前列醇组60例,在硬膜外麻醉成功后,直肠内放入米索前列醇400 ug,立即开始手术;催产素组60例,于胎儿娩出后立即子宫下段及宫体各注射催产素20IU,观察两组术中及术后2小时的出血量。结果:术中及术后2小时平均出血量:米索组为(173.2±93.2)ml,催产素组为(298.3±112.4)ml,两组间有显著性差异(P<0.01),而血压、呼吸、脉搏、血氧饱和度及新生儿评分无差异性(P>0.05)。结论:直肠给予米索前列醇能有效的预防剖宫产术中及术后出血,且给药方便、安全、无副作用。
Objective: To observe the effect of misoprostol in preventing postoperative bleeding in cesarean section. Methods: 120 cases of elective cesarean section were selected and randomly divided into misoprostol group and oxytocin group. In the group of misoprostol 60 cases, 400 cases of misoprostol were put into the rectum immediately after the successful epidural anesthesia, and 60 cases of oxytocin were given oxytocin immediately after the fetus was delivered. Su 20IU, observed two groups intraoperative and postoperative 2 hours of bleeding. Results: The average amount of bleeding during and after surgery was (173.2 ± 93.2) ml in misoprostol group and (298.3 ± 112.4) ml in oxytocin group, with significant difference between the two groups (P <0.01) There were no differences in respiration, pulse rate, oxygen saturation and neonatal score (P> 0.05). Conclusion: The administration of misoprostol through the rectum can effectively prevent cesarean section and postoperative bleeding, and is convenient, safe and without side effects.