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目的探讨纳洛酮与醒脑静联合抢救慢性阻塞性肺部疾病(COPD)并Ⅱ型呼吸衰竭的临床观察。方法将314例COPD并Ⅱ型呼吸衰竭患者随机分为两组,治疗组与对照组。治疗组162例,用纳洛酮联合醒脑静治疗,对照组152例用常规方法治疗。结果治疗组总有效率为96.3%,对照组总有效率为94.1%,两组差异有统计学意义(P<0.05)。动脉血气分析结果表明动脉血氧分压(PaO2)在干预后,治疗组的结果明显高于对照组,差异有统计学意义(P<0.05),而动脉血二氧化碳分压(PaCO2)的情况低于对照组,但差异无统计学意义(P>0.05)。结论纳洛酮与醒脑静联合治疗性阻塞性肺气肿并Ⅱ型呼吸衰竭临床疗效确切。
Objective To investigate the clinical efficacy of naloxone combined with xingnaojing in the treatment of chronic obstructive pulmonary disease (COPD) and type Ⅱ respiratory failure. Methods 314 patients with COPD and type Ⅱ respiratory failure were randomly divided into two groups, the treatment group and the control group. The treatment group of 162 cases, naloxone combined with Xingnao Jing treatment, control group of 152 patients treated by conventional methods. Results The total effective rate was 96.3% in the treatment group and 94.1% in the control group, with significant difference between the two groups (P <0.05). Arterial blood gas analysis showed that the PaO2 was significantly higher in the treatment group than in the control group after intervention (P <0.05), while the PaCO2 level in the arterial blood was low In the control group, but the difference was not statistically significant (P> 0.05). Conclusion Naloxone combined with xingnaojing is effective in treating obstructive pulmonary emphysema and type Ⅱ respiratory failure.