论文部分内容阅读
目的:探讨早期自然流产患者中绒毛染色体核型分析的重要性,为更好地开展优生优育工作奠定基础。方法:对本科2012年3月至2014年4月期间156例早期自然流产病例的绒毛组织样本进行细胞培养和G显带染色体核型分析。结果:156例早期自然流产的绒毛标本中,细胞培养成功147例,成功率为94.2%。其中共检出染色体异常核型67例,染色体异常率为45.5%(67/147),其中以三体型最为常见(32/67,47.8%)。单一流产与反复流产(≥2次)的异常胚胎比例分别为31.9%(22/69)和57.7%(45/78),P<0.05。染色体异常的胚胎中女性胚胎为48例,占48.9%(48/89),明显高于男性(32.8%,19/58)(P<0.05)。结论:胚胎的染色体异常是早期妊娠自然流产的主要原因之一,对于早期自然流产的胚胎开展染色体检测有利于临床上判断流产的原因,为优生优育工作提供理论依据和相关的指导方针。
Objective: To explore the importance of karyotype analysis of chorionic villi in patients with early spontaneous abortion, and lay the foundation for better prenatal and postnatal care. Methods: Cell culture and G - banding karyotype analysis of 156 cases of early spontaneous abortion in our department from March 2012 to April 2014 were performed. Results: In 156 cases of early spontaneous abortion, 147 cases were successfully cultured, with a success rate of 94.2%. Among them, 67 cases of chromosomal aberration karyotype were detected, the chromosomal abnormality rate was 45.5% (67/147), of which trisomy was the most common (32 / 67,47.8%). The proportion of abnormal embryos in single and repeated miscarriage (≥2 times) were 31.9% (22/69) and 57.7% (45/78) respectively, P <0.05. The number of female embryos in chromosomal abnormalities was 48, accounting for 48.9% (48/89), significantly higher than that of males (32.8%, 19/58) (P <0.05). Conclusion: Chromosome abnormalities of embryos are one of the main causes of spontaneous abortion in early pregnancy. To carry out chromosomal detection of early spontaneous abortion is helpful to determine the cause of miscarriage clinically and provide theoretical basis and relevant guidelines for prenatal and postnatal care.