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A facile method of preparation of benzimidazoles by microwave irradiation was described. The mixtures of o-phenylenediamine and carboxylic acids were heated by microwave irradiation, to give 2-substituted benzimidazoles with yields of 49%~93%. The reaction time was shortened to 3~6 min. However, the reaction of ethylenediamine with carboxylic acids did not give imidazoles but the N,N-diacyl ethylenediamines. The alphatic diamines lacked the activity to form imidazole ring. With adipic acid, intermolecular acylation took place to afford poly(ethylene adipamide).
A facile method of preparation of benzimidazoles by microwave irradiation was described. The mixtures of o-phenylenediamine and carboxylic acids were heated by microwave irradiation, to give 2-substituted benzimidazoles with yields of 49% ~ 93%. The reaction time was shortened to 3 ~ 6 min. However, the reaction of ethylenediamine with carboxylic acids did not give imidazoles but the N, N-diacyl ethylenediamines. The alphatic diamines lacked the activity to form imidazole ring. With adipic acid, intermolecular acylation took place to afford poly adipamide.