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目的:探讨四参养心汤联合降脂、抗血小板治疗对冠状动脉狭窄患者心肌缺血及心电图的影响。方法:选取2014年7月~2016年12月我院收治的冠状动脉狭窄患者70例为研究对象,采用随机数表法分为观察组和对照组各35例,对照组给予降脂、抗血小板等内科基础治疗,观察组在此基础上给予四参养心汤,对比两组治疗总有效率、心电图改善有效率及心肌缺血发作频率、心肌缺血持续时间、心肌缺血总负荷(TIB),应用汉密尔顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)评价两组治疗前后焦虑、抑郁情绪,同时观察不良反应。结果:观察组治疗总有效率、心电图改善有效率分别为88.57%、77.14%,均明显高于对照组68.57%、51.43%(P<0.05);观察组治疗后心肌缺血发作频率(1.02±0.11)次/24小时、心肌供血持续时间(2.24±1.57)min、TIB(10.28±1.22)(mm·min)/24小时较对照组明显减少(P<0.05);治疗后观察组HAMA、HAMD评分[(17.45±1.02)分、(19.81±1.04)分]与对照组比较均明显较低(P<0.05);两组不良反应发生率8.57%、5.71%比较无显著差异(P>0.05)。结论:四参养心汤联合降脂、抗血小板治疗可有效降低冠状动脉狭窄患者心肌缺血,改善其心点图及临床症状,减轻焦虑抑郁情绪,同时无明显不良反应,值得在临床推广应用。
Objective: To investigate the effect of Sifangyang Decoction combined with lipid-lowering and antiplatelet therapy on myocardial ischemia and electrocardiogram in patients with coronary artery stenosis. Methods: Seventy patients with coronary artery stenosis admitted to our hospital from July 2014 to December 2016 were selected as study objects. The random number table was divided into observation group (35 cases) and control group (35 cases). The control group was given lipid-lowering and anti-platelet And other medical basic treatment, the observation group was given on this basis four Senate Yang Tang, compared the two groups of total effective rate, the effective rate of ECG and myocardial ischemic attack frequency, duration of myocardial ischemia, total myocardial ischemic load (TIB ), HAMA and HAMD were used to evaluate the anxiety and depression before and after treatment, and the adverse reactions were observed. Results: The total effective rate of the observation group was 88.57% and 77.14%, respectively, which were significantly higher than that of the control group (68.57% and 51.43%, P <0.05). The frequency of myocardial ischemia in the observation group was 1.02 ± (2.24 ± 1.57) min, TIB (10.28 ± 1.22) (mm · min) / 24 hours were significantly lower than those in the control group (P 0. 05), and the levels of HAMA, HAMD (17.45 ± 1.02) points, (19.81 ± 1.04) points compared with the control group were significantly lower (P <0.05); the incidence of adverse reactions in the two groups was 8.57%, 5.71% was no significant difference (P> 0.05) . Conclusion: Sipang Yang Xin Decoction combined with lipid-lowering and anti-platelet therapy can effectively reduce myocardial ischemia in patients with coronary artery stenosis, improve its cardiac map and clinical symptoms, relieve anxiety and depression, and have no obvious adverse reactions, which is worthy of clinical application .