出血性脑卒中(Hemorrhagic stroke,HS)起病急骤、病情凶险,具有较高病死率和不良预后率特征,目前还没有令人满意的药物治疗方法。PTX3(Pentraxin-3)是正五聚蛋白超家族中的一员,内皮细胞、平滑肌细胞、脂肪细胞、成纤维细胞、单核巨噬细胞及树突细胞等均可分泌PTX3,能反映血管的炎症状态,并与神经和血管再生有关,对脑卒中起功能性修复作用,可能成为治疗HS的新靶点。 Hemorrhagic stroke (HS) is a rapidly onset and dangerous disease with high mortality and poor prognosis. Currently, there is no satisfactory drug treatment. PTX3 (Pentraxin-3) is a member of the pentraxin superfamily. Endothelial cells, smooth muscle cells, adipocytes, fibroblasts, mononuclear macrophages and dendritic cells all can secrete PTX3, which can reflect the inflammation of blood vessels State, and with nerve and vascular regeneration related to the functional repair of stroke, may be a new target for the treatment of HS.