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作者观察了两例慢粒急变和一例急变前患者的染色体变化。发现它们均为Ph~1阳性型慢粒。急变前即有少许细胞含异常染色体,较多细胞处于晚中期阶段。急变时1例有较多的含2个Ph~1的超二倍体,超出的多为3号染色体;另一例异常细胞为亚二倍体。
The authors looked at the chromosomal changes in two patients with chronic myeloma and one before the sudden change. They were all found to be Ph ~ 1 positive-type slow granules. A little before the rapid change of cells containing abnormal chromosomes, more cells in the late mid-stage. 1 case had more hyperploidy with 2 Ph ~ 1 in 1 case, more than chromosome 3; in the other case, the abnormal cells were sub-diploid.