本文以大鼠隐静脉为实验模型，于其腔内注入３：１浓度的消痔灵（简称“消”）或５％鱼肝油酸钠（简称“鱼”），光镜下观察与研究隐静脉的闭锁情况及注“消”后的组织学变化过程，并对上述两种硬化剂的毒性进行比较。结果表明：１．注“消”后第２８天，注“消”各剂量组隐静脉腔完全或大部分闭锁者均占１８．２８％，部分闭锁者均占４５．４５％。２．“消”的硬化效果比“鱼”差，而毒性比“鱼”低。３．注“消”后隐静脉产生无菌性炎症，内膜被破坏；继之腔内血栓形成并发生机化，同时管壁平滑肌及管周胶原纤维出现由变性至纤维增生并向腔内挤压的变化，使管腔闭锁或狭窄。实验结果为消痔灵注射治疗海绵型血管瘤的疗效、机理及其剂量与浓度的掌握提供了理论依据 In this paper, the rat saphenous vein as the experimental model in its cavity by injecting 3: 1 Xiaozhiling Ling (referred to as “elimination”) or 5% sodium morrhuate (referred to as “fish”), light microscopy and study of saphenous vein Of the closed situation and note “elimination” after the histological changes, and the toxicity of the two hardeners were compared. The result shows: 1. Note the “consumer” after 28 days, Note “eliminate” each dose group of all or most of the saphenous vein atresia accounted for 18.28%, 45.45% were partially blocked. 2. “Consumer” sclerosis effect than “fish”, and less toxic than the “fish”. 3. Note “disappear” after aseptic inflammation of the veins produce aseptic inflammation, endometrial destruction; followed by intraluminal thrombosis and the occurrence of mechanical, while walled smooth muscle and peritubular collagen fibrosis appear to fibrosis and extrusion to the cavity The changes that make the lumen atresia or stenosis. The experimental results provide a theoretical basis for the curative effect and mechanism of Xiaoyiling injection for the treatment of sponge hemangiomas and its dosage and concentration