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目的探讨血清基质金属蛋白酶(MMP)-1、MMP-2、组织金属蛋白酶抑制因子(TIMP)-1与女性年龄、骨密度(BMD)及骨转换生化指标之间的关系。方法用ELISA测定591名20～80岁女性的血清MMP-1、MMP-2、TIMP-1、骨碱性磷酸酶(BAP)、骨钙素(OC)和Ⅰ型胶原氨基末端肽(NTX)水平,用双能X线骨密度仪测定多骨骼部位的BMD。结果(1)MMP-1、MMP-2、TIMP-1与年龄呈正相关(均P＜0．01)。(2)按是否绝经分组结果表明：绝经后妇女MMP-2水平较绝经前妇女高[(1272±279)μg/L与(1141±290)μg/L,P＜0．01]。(3)MMP-2与BMD呈负相关(P＜0．05),但多元线性回归分析表明MMP-2不是BMD的预测因子。(4)MMP-2与血清BAP、OC、NTX正相关(均P＜0．01)。(5)绝经后骨质疏松症患者血清MMP-2水平高于年龄匹配的正常对照组、骨量减少组[(1466±313,1222±243,1282±220)μg/L,均P＜0．01]。结论血清MMP-2与骨转换生化指标相关联。血清MMP-2水平升高可能为高骨代谢转换过程(如绝经后骨质疏松症)中的一种伴随表现。
Objective To investigate the relationship between serum matrix metalloproteinase (MMP) -1, MMP-2, tissue inhibitor of metalloproteinase (TIMP) -1 and female age, bone mineral density (BMD) and biochemical markers of bone turnover. Methods The serum level of MMP-1, MMP-2, TIMP-1, BAP, OC and NTX in 591 women aged 20 to 80 were measured by ELISA. Level, measured by double energy X-ray absorptiometry BMD of multiple skeletal sites. Results (1) MMP-1, MMP-2 and TIMP-1 were positively correlated with age (all P <0.01). (2) According to the results of menopausal grouping, the level of MMP-2 in postmenopausal women was higher than that in premenopausal women (1272 ± 279 μg / L and 1141 ± 290 μg / L, P <0.01). (3) There was a negative correlation between MMP-2 and BMD (P <0.05), but multivariate linear regression analysis showed that MMP-2 was not a predictor of BMD. (4) MMP-2 was positively correlated with serum BAP, OC and NTX (all P <0.01). (5) The serum level of MMP-2 in postmenopausal osteoporosis patients was higher than that of the age-matched normal control group, with osteopenia (1466 ± 313,1222 ± 243,1282 ± 220) μg / L, all P <0 .01]. Conclusion Serum MMP-2 is associated with biochemical markers of bone turnover. Elevated serum levels of MMP-2 may be a concomitant manifestation in the process of high-bone metabolism (such as postmenopausal osteoporosis).