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目的探讨急性缺血性脑卒中(AIS)患者血浆中血小板微粒体(PMP)和内皮细胞微粒体(EMP)水平与其预后的关系。方法以德州市人民医院神经内科2013年3月至2015年6月收治的56例AIS患者(AIS组)和40例体检者(对照组)为研究对象。对所有研究对象进行问卷调查并抽取5 m L静脉血,采用流式细胞仪检测PMP和EMP含量。对AIS组进行入院和出院NIHSS评分,据此将AIS组分为预后不良和预后良好两类。采用Logistic回归分析探讨影响AIS预后的危险因素。结果 AIS组PMP和EMP水平显著高于对照组(P<0.05)。AIS组中预后良好患者的PMP和EMP水平显著低于预后不良的患者(P<0.05)。Logistic回归分析发现,糖尿病、高血压、PMP和EMP水平是影响AIS患者预后的独立预测因子。结论血浆PMP和EMP水平可能作为临床上评估AIS预后的指标。
Objective To investigate the relationship between the plasma levels of platelet microparticles (PMP) and endothelial cell microsomes (EMP) in patients with acute ischemic stroke (AIS) and their prognosis. Methods Fifty-six patients with AIS (AIS group) and 40 subjects (control group) were enrolled in the Department of Neurology, Dezhou People’s Hospital from March 2013 to June 2015. All subjects were surveyed and 5 m L venous blood was drawn, and the contents of PMP and EMP were measured by flow cytometry. The hospital admission and discharge NIHSS scores of AIS group were divided into two groups according to which the AIS group had poor prognosis and good prognosis. Logistic regression analysis was used to explore the risk factors affecting the prognosis of AIS. Results The levels of PMP and EMP in AIS group were significantly higher than those in control group (P <0.05). Patients with good prognosis in the AIS group had significantly lower levels of PMP and EMP than patients with poor prognosis (P <0.05). Logistic regression analysis found that diabetes, hypertension, PMP and EMP levels were independent predictors of prognosis in patients with AIS. Conclusions Plasma PMP and EMP levels may be used as an index to evaluate the prognosis of AIS clinically.