已知Ketoconazole(以下简称KC,一种咪唑衍化物)可以减少监护室病人的成人呼吸窘迫综合征(ARDS)发生率,实验进一步研究KC对白三烯B_4(LTB_4)、血栓素A(TXA_2)的生成以及前凝血质活力(PCA)的影响,其中LTB_4影响中性多形核细胞的浸润,TXA_2和PCA则与微血管血栓形成有关,上述均是ARDS的主要组织病理学现象。实验动物取Stanwood新西兰雄性白兔,用硫喷妥钠处死后,即作支气管肺泡灌洗,从中集取肺泡巨噬细胞(浓度为5～10×10~5个/ml), Ketoconazole is known to reduce the incidence of adult respiratory distress syndrome (ARDS) in intensive care units and further investigate the effects of KC on leukotriene B 4 (LTB 4), thromboxane A (TXA 2) (PCA). LTB_4 affected the infiltration of neutrophils, TXA_2 and PCA were related to microvascular thrombosis, all of which were the main histopathological phenomena of ARDS. The experimental animals were taken from Stanwood New Zealand male rabbits and sacrificed with thiopental for bronchoalveolar lavage. Alveolar macrophages (5-10 × 10-5 cells / ml)