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目的观察717解毒合剂对蝮蛇咬伤大鼠血清心肌酶谱的干预作用。方法实验研究采用24只大白鼠局部注射蝮蛇毒造模后,分为中药组、血清组和中药加血清组3组进行治疗,从大鼠球后静脉取血,采用ELISA法检测大鼠模型在实验不同时段血清心肌酶谱的水平,并对实验数据进行统计分析,得出结论。结果模型组血清CK、CK-MB、LDH、AST的含量高于正常组(P<0.05)。治疗后与模型组比较,各治疗组血清CK、CK-MB、LDH、AST含量降低(P<0.05),且以中药加血清组疗效最好,其次为中药组。结论 717解毒合剂可以降低蛇伤大鼠血清CK、CK-MB、LDH、AST值,其解毒排毒,纠正心肌损伤的效果明显,是治疗蝮蛇咬伤的有效药物。
Objective To observe the intervention effect of 717 Jiedu mixture on Serum Myocardial Enzymes of vitexin rats. Methods Experimental study using 24 rats local injection of Agkistrodon flava model, divided into traditional Chinese medicine group, serum group and traditional Chinese medicine plus serum group three groups for treatment, from the posterior vena cava in rats, the ELISA method was used to detect the rat model Serum levels of myocardial enzymes at different time points were tested, and statistical analysis of the experimental data was carried out to draw conclusions. Results The levels of serum CK, CK-MB, LDH and AST in model group were higher than those in normal group (P <0.05). Compared with the model group, the contents of CK, CK-MB, LDH and AST in each treatment group decreased after treatment (P <0.05), and the best effect was obtained with Chinese medicine plus serum group, followed by the traditional Chinese medicine group. Conclusions 717 Jiedu Heji can reduce serum CK, CK-MB, LDH and AST of snake-wound rats, and has obvious effect of detoxification and detoxification to correct myocardial injury. It is an effective drug for the treatment of vitex bites.