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探讨血管紧张素转化酶（ＡＣＥ）基因插入／缺失（Ｉ／Ｄ）多态性与高血压患者左室肥厚的关系。方法用多聚酶链式反应（ＰＣＲ）方法检测６１例高血压患者ＡＣＥ基因１６内含子中Ａｌｕ重复片段的Ｉ／Ｄ情况，按其存在与否将患者分为插入型纯合子（ＩＩ），缺失型纯合子（ＤＤ）或杂合子（ＩＤ）３组。对不同组间血压（ＢＰ）、体重指数（ＢＭＩ）和左室重量指数（ＬＶＭＩ）进行比较。结果ＡＣＥ基因ＩＩ、ＩＤ、ＤＤ３种不同基因型患者的ＢＰ和ＢＭＩ虽相似，但ＡＣＥ基因ＤＤ型者ＬＶＭＩ明显高于Ｉ型者（Ｐ＜０．０５）。结论ＡＣＥ基因Ｉ／Ｄ多态性与高血压患者左室肥厚程度相关，可能是左室肥厚发生的遗传学基础之一。
To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion / deletion (I / D) polymorphism and left ventricular hypertrophy in hypertensive patients. Methods The polymerase chain reaction (PCR) method was used to detect the I / D of Alu repeat in ACE gene 16 in 61 hypertensive patients. According to their presence or absence, the patients were divided into insertion homozygote (II), deletion Type homozygous (DD) or heterozygous (ID) 3 groups. Blood pressure (BP), body mass index (BMI) and left ventricular mass index (LVMI) were compared between different groups. Results Although the BP and BMI of ACE genotype II, ID and DD3 genotypes were similar, the LVMI of ACE gene DD genotype was significantly higher than that of genotype I (P <0.05). Conclusion The ACE gene I / D polymorphism is associated with the degree of left ventricular hypertrophy in hypertensive patients and may be one of the genetic basis of left ventricular hypertrophy.