【摘 要】
：
Chromatographic purification of Sigesbeckia glabrescens extracts led to three undescribed ent-pimarane diterpenoid dimers,named glabreside A—C (1-3).Their structures were confirmed by comprehensive spectroscopic analyses,and the structures of compound 1 a
【机 构】
：
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning
论文部分内容阅读
Chromatographic purification of Sigesbeckia glabrescens extracts led to three undescribed ent-pimarane diterpenoid dimers,named glabreside A—C (1-3).Their structures were confirmed by comprehensive spectroscopic analyses,and the structures of compound 1 and 3 were confirmed by X-ray crystallography.The results of anti-inflammatory activity assay showed that glabreside C (3) exhibited the most potent inhibition activity on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in BV2 microglia compared with the other two compounds.Glabreside C also increased the protein expression level of heme oxygenase-1 (HO-1),and sup-pressed inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) in LPS-stimulated BV2 cells.Mechanistically,glabreside C exerts its anti-inflammatory effect by inhibiting AKT/MAPKs signaling pathway.These findings indicate the vital role of ent-pimarane diterpenoid dimers in explaining the anti-inflammatory activity of S.glabrescens and provide important evidence for further devel-opment and utilization of Sigesbeckiae Herba.These results also suggest that glabreside C is a potential lead compound for an-ti-inflammatory drugs.
其他文献
四川省大地构造演化研究已有百余年的历史,不同时期、不同学派在不同的尺度上提出了不同的大地构造单元划分方案,其中仍存在诸多争议.本文结合近30年来四川省特别是造山带地区开展的蛇绿岩和洋板块地层等调查和研究成果,以李廷栋所提出的洋板块地质学理念为指导思想,以区域主构造事件形成的优势大地构造相的时空结构组合和存在状态为基本原则,划分出秦-祁-昆造山系、勉县-略阳对接带、北羌塘-三江造山系以及扬子克拉通4个一级构造单元,包括11个二级构造单元和24个三级构造单元.
The first asymmetric decarboxylative[3+2]-cycloaddition of ethynyl indoloxazolidones with carboxylic acids has been developed un-der synergistic catalysis of copper and chiral Lewis base.This protocol provides a direct and modular approach to biologically
Kosinostatin (KST) contains an uncommon aminopyrrole moiety,whose biosynthesis has remained elusive.Herein,aminopyrrolinic acid,which was generated by an L-ectoine synthase-like enzyme KstB3 via cyclization of L-glutamine,was identified to be the real sub
A new cyclic thiopeptide,berninamycin F (3),three new linear thiopeptides,berninamycins G—I (4-6),and two known berninamycin derivatives,berninamycins C and D (1 and 2) were isolated from Streptomyces sp.CPCC 203702.Their structures were elucidated throug
Polyethylene glycol (PEG) as phase change material (PCM) and carboxyl-rich carbon (RHTC) with different carboxyl content was intro-duced to prepare RHTC/PEG composites.The composites have high thermal conductivity,photothermal conversion ability,and im-pr
We report herein the precision synthesis and phase behaviors of multi-tailed B2AB2-type regio-isomeric giant surfactants consisting of a hydrophilic polyhedral oligomeric silsesquioxane (POSS) head tethered with four hydrophobic polystyrene (PS) tails.The
Herein,we report an efficient,tunable system for electrochemical reduction of ketones and phthalimides at room temperature with-out the need for stoichiometric external reductants.By utilizing NaN3 as the electrolyte and graphite felt as both the cathode
A green and efficient photolabile protecting group (PPG)-mediated glycosidation approach for the synthesis of 2-deoxy-glycosides is reported.By employing ortho-nitrobenzyl carbonate (oNBC) as PPG,N,N-dimethylformamide (DMF)-modulated SPhosAuNTf2-pro-moted
Imine-linked covalent organic frameworks (COFs) have attracted extensive attention due to designable structures,tunable properties,and excellent thermal and chemical stability.They were typically obtained as insoluble and unprocessable powders,which serio
A phytochemical investigation on the seeds of Sophora alopecuroides led to obtaining fourteen structurally diverse matrine-based al-kaloids (1-14),including eight new ones (1,6,8-12,14).Notably,alopecuroide F (1) represents the first dimeric matrine-type