本文报道用双盲法研究巯甲丙脯酸对充血性心衰患者,血清地高辛浓度、肾功能及体钾的作用,并在开放试验中,研究该药对地高辛肾清除率的影响。方法:研究A-20例均为病程超过半年的Ⅲ-Ⅳ级充血性心衰患者,男14例,女6例,平均年龄62±12岁。研究分四步:(1)准备阶段二周,用地高辛,利尿剂及补钾以稳定病情;(2)给予巯甲丙脯氨酸,开始6.25毫克/次,日3次,继后每人均调整到一固定量(平均每日总量93.75毫克),作为时六周的开放试验;(3)按双盲法随机将病人分为二组,按(2)的给药方法和剂量分 This article reports a double-blind study of the effects of captopril on patients with congestive heart failure, serum digoxin concentrations, renal function, and body potassium. In an open trial, the effect of captopril on renal clearance of digoxin influences. Methods: A-20 patients with stage Ⅲ-Ⅳ congestive heart failure over half a year were studied. There were 14 males and 6 females with an average age of 62 ± 12 years. Study in four steps: (1) preparation phase two weeks, with digoxin, diuretics and potassium to stabilize the condition; (2) given captopril, beginning 6.25 mg / time, 3 times a day, followed by each Per capita adjusted to a fixed amount (average daily total 93.75 mg), as a six-week open trial; (3) double-blind randomized patients were divided into two groups, according to (2)