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目的:比较5-氟尿嘧啶联合铂类(PF)、吉西他滨联合铂类(GP)及多西他赛联合铂类(DC)3种方案诱导化疗联合放疗治疗局部晚期鼻咽癌的近期疗效。方法:68例II-IVA期病理确诊为鼻咽癌的患者分为3组,PF组16例,GP组30例,DC组22例。每组采用不同的诱导化疗的方法化疗2~3程后予根治性放疗。结果:3组诱导化疗结束后及放疗后3月鼻咽及颈部淋巴结的缓解率比较,差异无统计学意义(P>0.05),毒副反应方面PF的III度及以上放射性口腔粘膜炎较其它两组稍高,但差异无统计学意义(P>0.05)。结论:PF、GP及DC这3种方案诱导化疗联合放疗治疗局部晚期鼻咽癌可耐受且近期疗效相当,有待进一步临床观察。
Objective: To compare the short-term effects of 5-fluorouracil combined with platinum (PF), gemcitabine combined with platinum (Platinum) and docetaxel combined with platinum (3) in inducing chemotherapy and radiotherapy for locally advanced nasopharyngeal carcinoma. Methods: Sixty-eight patients with stage II-IVA pathological diagnosis of nasopharyngeal carcinoma were divided into three groups: 16 in PF group, 30 in GP group and 22 in DC group. Each group with different methods of induction chemotherapy chemotherapy 2 to 3 after radical radiotherapy. Results: There was no significant difference in the remission rates of nasopharyngeal and cervical lymph nodes between the 3 groups after induction chemotherapy and 3 months after radiotherapy (P> 0.05). The toxicity and side effects of radioactive mucositis III and above of PF The other two groups slightly higher, but the difference was not statistically significant (P> 0.05). Conclusion: PF, GP and DC are the three kinds of chemotherapy-induced chemotherapy combined with radiotherapy for the treatment of locally advanced nasopharyngeal carcinoma and the short-term efficacy is quite similar to be further clinical observation.