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目的 :研究去纤软肝胶囊抗肝纤维化作用。方法 :制备大鼠肝纤维化模型 ,以去纤软肝胶囊治疗 ,观察肝组织病理形态及血清肝纤维化指标等变化 ;并对胶原、网状、弹性纤维面积进行真彩图像定量分析。结果 :治疗组大鼠肝纤维化程度减轻 ,胶原纤维含量下降 ,血清透明质酸 (HA) ,层粘蛋白 (LN) ,Ⅲ型前胶原 (PcⅢ )、Ⅳ型胶原(CⅣ )含量及丙氨酸转氨酶活性显著下降 ,白蛋白含量显著上升 ,与模型组大鼠差异显著 (均P <0 .0 1)。结论 :去纤软肝胶囊有一定的抗肝纤维化作用。
Objective: To study the anti-hepatic fibrosis effect of Defibrown soft liver capsule. Methods: The rat model of hepatic fibrosis was prepared. The changes of pathological changes of hepatic tissue and the indexes of liver fibrosis were observed with the treatment of defibrillating Ruangan Capsule. The true color images of the collagen, reticular and elastic fibers were quantitatively analyzed. Results: The liver fibrosis, the content of collagen fibers, the content of HA, Pc, CⅣ and the contents of serum ammonia, Acid aminotransferase activity decreased significantly, albumin content increased significantly, and the model group, the difference was significant (P <0.01). Conclusion: Defibrillating soft capsules have anti-hepatic fibrosis effect.