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目的探讨c-met蛋白与食管鳞癌病人临床分期及细胞分化程度的相关性。方法选择于本院就诊的食管鳞癌患者100例,采用免疫组织化学检测食管癌组织中c-met蛋白的表达情况,根据c-met蛋白的平均表达水平将食管癌患者分为c-met阴性组(c-met蛋白不表达)和c-met阳性组(c-met蛋白有表达),并对这两组病人的临床病理特征、总生存时间进行比较。结果对100名食管鳞癌患者(男67例,女33例,平均年龄为59岁)的实验结果进行分析。c-met蛋白表达阴性组51例,c-met蛋白表达阳性组49例。c-met蛋白表达阳性者较c-met蛋白表达阴性者的临床分期更高,分化程度更低。Kaplan-Meier生存函数曲线表明,阳性组患者生存率较低值组显著降低c-met蛋白表达阴性组中位生存时间为48.2月,蛋白表达阳性组为30.9月,差异具有统计学意义(P<0.05)。COX回归分析表明,c-met过表达是食管鳞癌患者总生存的独立不良预后因素(HR:2.34,95%CI:1.63~4.54,P<0.05)。结论 c-met蛋白在食管鳞癌组织中的表达与食管癌的分期和分化程度密切相关,并且可能是患者随访期间生存时间的独立预测因子。
Objective To investigate the correlation between c-met protein and clinical stage and cell differentiation in patients with esophageal squamous cell carcinoma. Methods 100 patients with esophageal squamous cell carcinoma were selected for this study. The expression of c-met protein in esophageal cancer tissue was detected by immunohistochemistry. According to the average expression of c-met protein, esophageal cancer patients were divided into c-met negative (C-met protein was not expressed) and c-met positive group (c-met protein expression), and the two groups of patients with clinical and pathological features, the total survival time were compared. Results The results of 100 experimental esophageal squamous cell carcinoma patients (67 males and 33 females with an average age of 59 years) were analyzed. Fifty-one patients with negative c-met protein expression and 49 patients with positive c-met protein expression. Patients with positive c-met protein expression had a higher clinical stage and lower degree of differentiation than those with negative c-met protein expression. The Kaplan-Meier survival curve showed that in the positive group, the median survival time was significantly lower in the lower group than in the negative group (48.2 months), and the positive expression was 30.9 months (P < 0.05). COX regression analysis showed that c-met overexpression was an independent, adverse prognostic factor for overall survival in patients with esophageal squamous cell carcinoma (HR: 2.34, 95% CI: 1.63-4.54, P <0.05). Conclusions The expression of c-met protein in esophageal squamous cell carcinoma is closely related to the staging and differentiation of esophageal cancer and may be an independent predictor of survival during follow-up.