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目的探讨HPV感染与口咽部鳞状细胞癌(OPSCC)预后的关系。方法检索中外文数据库,获得有关HPV感染与OPSCC预后关系的文献,应用Meta分析计算合并HR及其95%CI。结果共15篇合格文献纳入本研究,累计OPSCC病例1 725例,其中HPV阳性表达746例,阳性率43.25%。HPV阳性的OPSCC患者有较低的死亡风险(合并HR=0.316,95%CI:0.236~0.395)和肿瘤复发风险(合并HR=0.316,95%CI:0.229~0.403)。结论 HPV阳性可能是OPSCC预后较好的因素。
Objective To investigate the relationship between HPV infection and the prognosis of oropharyngeal squamous cell carcinoma (OPSCC). Methods The Chinese and foreign language databases were searched and the literature on the relationship between HPV infection and the prognosis of OPSCC was obtained. Meta-analysis was used to calculate the combined HR and its 95% CI. Results A total of 15 qualified articles were included in this study. There were 1 725 cases of OPSCC cases, of which 746 were positive for HPV. The positive rate was 43.25%. Patients with HPV-positive OPSCC had a lower risk of death (combined HR = 0.316, 95% CI: 0.236 to 0.395) and risk of tumor recurrence (combined HR = 0.316, 95% CI: 0.229 to 0.403). Conclusion HPV-positive may be a good prognostic factor for OPSCC.