血管的内皮细胞(EC)可以防止循环凝血因子与内皮下凝血活化剂(如胶原等)相接触,可以抑制血小板的粘附聚集,并通过前列腺素PGI的产生以及凝血酶和因子Ⅸ,Ⅹ的灭活,在控制血液凝块形成中起着作用。而EC也象管壁的其他细胞一样含有凝血活酶的活性,这种活性在静脉EC中业已得到证明,而在动脉EC中也可能存在。作者在本文中报告了他研究内皮细胞中凝血活酶的合成问题。结果表明,在未受刺激的EC中凝血活酶的活性很低(0.5—5u/mg蛋白),且不因细胞培养的天数(4—14天)和孵育时间(0.5—24小时)而改变。但12-0-十四酰-13乙酸副醇酯(12-O-tetraolecanoyl-phorbol-13- Endothelial cells (ECs) of blood vessels prevent circulating clotting factors from contacting with subendothelial coagulation activators (such as collagen), inhibiting the platelet adhesion and aggregation, and through the production of prostaglandin PGI and the action of thrombin and factors IX, X Inactivated, plays a role in controlling blood clot formation. EC, like other cells in the wall, also contains thromboplastin activity, which has been demonstrated in venous ECs and may also be present in arterial ECs. The authors report in this paper that he is studying the synthesis of thromboplastin in endothelial cells. The results show that the thromboplastin activity is very low (0.5-5 u / mg protein) in unstimulated EC and does not change due to days of cell culture (4-14 days) and incubation time (0.5-24 hours) . But 12-O-tetraolecanoyl-phorbol-13-