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目的调查辽宁省一般人群尿中铜、锌水平,分析其人群分布特点。方法将辽宁省划分为东、中、西部地区,采用多阶段分层整群随机抽样的方法,于2009—2010年辽宁省东、中、西部抽取1691名对象进行问卷调查,并采集尿液样品。用电感耦合等离子体质谱法检测尿中铜、锌含量,通过统计分析研究一般人群尿中铜、锌的分布水平。结果调查对象尿铜几何均数(95%CI)为10.59μg/L,中位数(P50)为10.70μg/L;男性尿铜几何均数显著高于女性(P<0.01);不同年龄组人群尿铜几何均数差异具有统计学意义(P<0.01),其中17~20岁年龄组尿铜最高,21~30岁年龄组尿铜最低;辽宁省东、中、西部地区人群尿铜几何均数差异有统计学意义(P<0.01),分别为10.69、8.71和12.73μg/L;吸烟与饮酒特征中人群尿铜几何均数差异均有统计学意义(P<0.01)。尿锌95%CI为77.26μg/L,P50为85.09μg/L;男性尿锌几何均数显著高于女性(P<0.01);不同年龄组人群尿锌几何均数差异具有统计学意义(P<0.01),其中6~12岁年龄组尿锌最高,31~45岁年龄组尿锌最低;辽宁省东、中、西部地区人群尿锌几何均数差异具有统计学意义(P<0.01);吸烟与饮酒特征中人群尿锌几何均数差异均有统计学意义(P<0.05)。结论辽宁省一般人群尿中铜、锌水平在不同性别、年龄、区域特征中均存在差异。
Objective To investigate urinary levels of copper and zinc in the general population in Liaoning Province and analyze the distribution characteristics of their populations. Methods Liaoning Province was divided into eastern, central and western regions. A total of 1691 subjects from the eastern, central and western Liaoning Province from 2009 to 2010 were selected for questionnaire survey by multi-stage stratified random sampling method. Urine samples . The contents of copper and zinc in the urine were detected by inductively coupled plasma mass spectrometry. The distribution of urinary copper and zinc in the general population was analyzed by statistical analysis. Results The urinary copper geometric mean (95% CI) was 10.59μg / L and the median (P50) was 10.70μg / L. The geometric mean of urinary copper in males was significantly higher than that in females (P <0.01) Urine copper geometric mean difference between the groups was statistically significant (P <0.01), of which 17 to 20 age group, the highest urinary copper, 21 to 30 age group, the lowest urinary copper; Liaoning Province, the eastern, central and western regions of urinary copper geometry (P <0.01), which were 10.69, 8.71 and 12.73μg / L, respectively. There was significant difference in urinary copper geometric mean between smoking and drinking characteristics (P <0.01). The urinary zinc 95% CI was 77.26μg / L, P50 was 85.09μg / L, and the urinary zinc geometric mean of male was significantly higher than that of female (P <0.01). The geometric mean of urinary zinc in different age groups was statistically significant (P <0.01). Urinary zinc was the highest in 6 ~ 12 age group and lowest in 31 ~ 45 age group. There was significant difference in geometric mean of urinary zinc in population from east, middle and west of Liaoning Province (P <0.01). Smoking and drinking characteristics of urine zinc population geometric mean differences were statistically significant (P <0.05). Conclusion Urine levels of copper and zinc in the general population of Liaoning Province are different in different gender, age and regional characteristics.