肝衰竭是多种因素引起的严重肝脏损害,导致其合成、解读、排泄和生物转化等功能发生严重障碍或失代偿,出现以凝血功能障碍、黄疸、肝性脑病、腹水等为主要表现的一组临床证候群[1]。越来越多的证据显示免疫介导的肝损伤在肝衰竭的发病中起到了重要作用[2]。近年来,对肿瘤坏死因子α(tumour necrosis factor-α,TNF-α)的研究越发深 Liver failure is caused by a variety of serious liver damage, leading to its synthesis, interpretation, excretion and biotransformation and other serious disorders or decompensation, there coagulation disorders, jaundice, hepatic encephalopathy, ascites, etc. as the main performance A group of clinical syndromes [1]. There is growing evidence that immune-mediated liver injury plays an important role in the pathogenesis of liver failure [2]. In recent years, more and more research on tumor necrosis factor-α (TNF-α)